An Rh-negative woman wants to predict her offspring's Rh genotype. Considering her husband has the genotype DCce, what is the husband's most likely Rh genotype?

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To understand why the husband's most likely Rh genotype is R0r', it's important to review the Rh blood group system and how genotypes are structured.

In the Rh system, the most significant antigens are D, Cc, and E. Individuals can inherit Rh factors in different ways that determine their phenotype and genotype. The reference alleles are designated as R (for Rh positive) and r (for Rh negative). The Rh-positive individuals can have one of several genotypes which include:

  • R1 (Dce)
  • R2 (DcE)
  • R0 (dce)
  • r' (DCE)
  • r (devoid of D antigen)

In this case, the husband has the genotype DCce, suggesting that he has at least one Rh D antigen present, indicating that he is Rh positive. The options presented indicate various combinations of Rh antigens.

The combination of alleles R0r' (dce and DCE) would allow for a father to express the DCc allele while carrying recessive alleles that can express e. In the Rh system, the presence of an Rh D antigen (which is evident in the husband's genotype) indicates a positive Rh factor.

If the woman is

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