Given the Rh phenotyping results (D=0, C=+, E=+, c=+, e=+, f=0), what is the most likely genotype?

The Rh phenotyping results indicate the presence and absence of specific antigens on the red blood cells. In this scenario, we have the following results: D=0, C=+, E=+, c=+, e=+, f=0.

To interpret these results in terms of genotype, it’s essential to understand the Rh system. The ‘D’ antigen is the primary antigen, while ‘C’, ‘c’, ‘E’, and ‘e’ are additional antigens in the Rh blood group system. The notations for genotypes (such as rr, r'r, r''r, and r'r") represent the different combinations of these alleles.

When looking at the D antigen being absent (D=0), the most relevant genotype is ‘rr’, which represents a homozygous condition for the d allele (D-negative). However, the presence of the C, c, E, and e antigens (C=+, E=+, c=+, e=+) suggests that there are Rh antigens present and that the genotype is not homozygous for the d allele.

The genotype 'r'r"' indicates a heterozygous condition, accounting for both the presence of the Cc and Ee antigens while