The family study illustrates which type of Lutheran Null inheritance?

The family study illustrates an autosomal dominant inhibitor when referring to Lutheran Null inheritance, specifically the ln(Lu) phenotype. In this context, individuals with the Lutheran phenotype have various types of antigens on their red blood cells, which are influenced by the presence or absence of specific genes at the Lutheran blood group locus. The ln(Lu) variant represents a dominant inheritance pattern, where one copy of the allele is sufficient to inhibit the expression of the Lutheran antigens.

Families exhibiting the Lutheran Null phenotype typically demonstrate this autosomal dominant inhibitor effect, where the expression of the Lutheran antigens can be disrupted by the presence of just one dominant allele. This is significant in transfusion medicine, as individuals with this phenotype can lack Lutheran antigens and may produce antibodies against them, posing challenges in blood transfusion compatibility.

Understanding this inheritance pattern aids in the genetic counseling of families at risk for having individuals with the Lutheran Null phenotype and assists in the interpretation of blood group typing in clinical situations.