What do the lab results indicate for a mother with O Neg blood type, Anti-D titer=2, and an A Pos infant with a negative DAT?

The presence of an Anti-D titer of 2 in a mother with an O negative blood type and a positive A positive infant indicates some level of Rh sensitization, but this is not definitive on its own. A titer of 2 suggests that the mother's immune response against RhD antigens is relatively low; however, the health of the infant must also be considered.

The critical factor to note here is the negative direct antiglobulin test (DAT) in the infant. A negative DAT implies that there are no detectable antibodies attached to the infant's red blood cells, indicating that the infant has not suffered from hemolysis due to Rh incompatibility at this point. Thus, the infant is not currently in distress due to the mother’s immunological response.

Determining candidacy for Rh immunoglobulin (RhIg or RhlG) depends on several factors: the mother's titer level, the fetal cells present in circulation, and the infant's condition. Because the mother's titer is low and the infant has a negative DAT, further assessment is warranted to make an informed decision regarding the need for RhIg.

This situation exemplifies why additional investigation is necessary to evaluate whether the mother should receive RhIg, as further lab results could