When HLA-A 1 and HLA-88 are found more frequently than expected, it is known as?

Linkage disequilibrium refers to a situation where certain combinations of alleles or genetic markers are found together in a population more frequently than would be expected based on the individual frequencies of each allele. This phenomenon often occurs due to historical factors such as population structure or evolutionary forces that maintain these allele combinations, resulting in a non-random association between them.

In the context of HLA-A 1 and HLA-88 being found together more frequently than expected, it suggests that these two loci are inherited together more often than random chance would predict. This can happen when genes are located close to each other on the same chromosome, minimizing the chances of being separated during recombination events in meiosis.

Linkage disequilibrium is important in various fields, including genetics, epidemiology, and anthropology, because understanding the relationship between alleles can inform us about population history, disease susceptibility, and can be utilized in mapping genetic traits.