Which of the following statements is true regarding GVHD in patients with HSCT?

Graft-versus-host disease (GVHD) is a serious condition that can occur in patients who have received a hematopoietic stem cell transplant (HSCT) when donor immune cells recognize the recipient's tissues as foreign. Statement C accurately reflects the potential severity of GVHD, highlighting that it can lead to significant complications, including pancytopenia. Pancytopenia is a condition characterized by a reduction in red blood cells, white blood cells, and platelets, which can arise from the damage done to the bone marrow by the donor T cells attacking the recipient's tissues. This illustrates the critical impact GVHD can have on a patient's overall health and well-being.

In contrast, the other statements do not accurately represent the clinical reality of GVHD. While some cases might present with minor symptoms, GVHD can have a wide-ranging and severe impact, which contradicts the notion of typically benign outcomes. Additionally, transfusion-related GVHD is generally considered to be more acute and immediate in onset, and it may result in rapid progression to severe illness compared to the chronic nature of HSCT-related GVHD, which can evolve and cause a variety of complications. Finally, skin involvement is just one of several manifestations of GVHD, which can